Hohenheim was mentioned for the first time in a document when Egilolf von Hohenheim gifted a piece of land to the Hirsau Monastery.
Paracelsus is probably the best-known Hohenheimer. Born as Theophrast von Hohenheim, starting in 1529 he called himself Paracelsus.
The Hohenheim Castle was burned down in the Thirty Years War.
The imperial official Emanual Garb purchased Hohenheim.
From 1772 until 1793, Duke Carl Eugen von Württemberg had the Palace and parks erected for his later wife Franziska and himself.