Genome Editing

Since its inception, the field of genetic engineering has introduced DNA to plenty of nips, tucks, and modifications all in the name of science. The latest evolution of these, genome editing, might be the most promising. Follow our favorite highlights in this rapidly moving application.

Check out the genome editing highlight reel on EpiGenie starring TALEs, CRISPR, and ZFNs.

2012-09-27 16:09:06

The State of Epigenetic Editing

The concept of systematically manipulating epigenetic marks to modulate gene expression is injecting some air back into the gene therapy balloon that has deflated a bit over the years.

2013-04-24 16:09:06

Genome Editing with the CRISPR/Cas System in Zebrafish

CRISPR/Cas is getting a lot of attention lately as a way to insert or delete genomic sequences in mammalian cells, but what about in model organisms? A new paper now shows that it works well in zebrafish and suggests it could be a new “go-to” method in other models as well.

2013-06-25 08:16:58

CRISPRi: The User-Friendly Transcriptional Repressor

So far CRISPR/Cas has shown great potential as it can work better than other methods, is easier to use, and is starting to be applied to model organisms. However, a talented group from UCSF has teamed up with some of the pioneers to show that we’ve only seen the tip of the iceberg when it comes to CRISPRs potential.

2013-11-16 08:16:58

Epigenetic Editing Targets DNA Demethylation, Induces Gene Expression

Controlling the expression of your gene of interest with a targeted epigenetic modifier has long been a dream of many. So a cunning team used fusions of designer DNA binding domains and the TET family (1, 2, 3) to target epigenetically silenced genes (ICAM-1, EpCAM).

2014-02-05 16:09:06

World’s First CRISPR Monkeys

The Crispr/Cas9 genetic engineering system has gotten a lot of buzz lately for its potential in epigenetic editing and now a team of researchers in China have just made a huge breakthrough, using the technique to create genetically engineered monkeys.

2014-03-10 16:09:06

Zinc Fingers Clinch Clinical Gold Medal Against HIV

Deploying Zinc Finger Nuclease (ZFN) genome editing techniques, researchers have edited the CCR5 ‘trojan horse’ receptor that HIV uses to infect our immune system’s vital CD4 T cells.

2014-04-09 16:09:06

CRISPR/Cas9 Caught Causing A Cure

The CRISPR/Cas9 system has ‘cured’ it’s first human related disease in mice by correcting a disease-related mutation and creating a healthy phenotype.

2014-04-22 16:09:06

DNA Cubes May Take Genome Editing Outside the Box

Through the use of some creative chemistry researchers have devised DNA cubes that can deliver molecular packages. A team crafted a piece of DNA origami that will only release it’s molecular payload when triggered by a specific mRNA.

2014-05-15 16:09:06

Genome Editing & iPSCs Reveal Matters of the Heart

A fusion of the CRISPR/Cas9 genome editing system and induced pluripotent stem cells (iPSC) creates a “heart-on-chip” technology that’s able to model the precise mutation causing a heart abnormality and use it to generate some synthetic hearts from patients for groundbreaking observations.

2014-06-23 08:16:58

Webinar: Genome Editing in Epigenetics

Dr. Marianne Rots provides an informative overview of the current state of epigenetic editing approaches.

Genome Editing

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