Epigenetics in Stem Cells

Epigenetics and stem cell biology

Stem Cells are a hot topic these days. Here we provide a history of epigenetic breakthroughs in this interdisciplinary field.

2010-08-03 10:15:15

Uncovering 5hmC’s Link to Stem Cell Self-Renewal

UNC scientist Shinsuke Ito and his colleagues first verified that both Tet1 and Tet2 reduced 5mC levels in vitro, and showed that this activity was conserved in humans and mice.

2010-08-04 10:15:15

iPS Cells Can’t Escape Their miRNA Pasts

Hart and colleagues make a strong case that although iPS cells express pluripotency markers and behave very similar to hESCs, there are still key transcriptional differences between the two.

2010-10-28 10:15:15

Pardon the Epigenetic Disruption

By watching for changes at certain loci during normal development, and then comparing that response after treatment with potential epigenetic disruptors, Dr. Hemberger discusses a reporter system to find agents that cause epigenetic damage.

2010-11-08 10:15:15

Stem Cells Heartbroken Without miR-499

Human embryonic stem cells (hESCs) may one day be used to help regenerate damaged heart tissue post-infarction, but before that can happen there is still much to learn about turning hESCs into full-fledged cardiomyocyte cells, and how miRNAs are involved. So, to learn more about how they tick the Stanford scientists decided to study the miRNA profiles of stem cell derived cardiomyocytes (hESC-CMs

2010-11-19 10:15:15

miR-23a,27a,24-2 Cluster is Bad to the Bone

A new study reveals that the miRNA 23a,27a,24-2 cluster is at the center of a regulatory network that controls osteoblast differentiation

2010-12-15 10:15:15

miR-200a Takes Down Cancerous Stem-like Transition

Epithelial-mesenchymal transition is thought to be the point where cancer metastasis kicks off and now Dr. Xia reports that miRNA-200a runs the show when it comes to keeping that dangerous transition in check.

2011-01-17 10:15:15

Stem Cells Can’t Hold Their Liquor

Researchers at Indiana University looked at alcohol’s effect on neural stem cells (NSCs) during development and determined that not only does alcohol change methylation patterns, but it blocks the necessary methylation programming changes that normally occur as NSCs differentiate.

2011-01-20 10:15:15

Ta-da! Blood Cells Transform into iPSCs

When U.S. and Chinese researchers poked around the DNA of human CD34+ cells from umbilical cord blood and adult blood, they found that the promoters’ methylation patterns looked a heck of a lot like those in embryonic stem cell and iPSC lines.

2011-02-02 10:15:15

MethylC-Seq Delivers First Single Base Resolution Methylation Profiles of iPSCs

Researchers in California and Wisconsin found that induced pluripotent stem cells (iPSCs) generated from old somatic cells aren’t quite the same as youthful embryonic stem cells (ESCs)—the epigenetics are “off”.

2011-02-25 10:15:15

Turning Back the Clock: Epigenetics, iPSCs and Aging

Researchers at the Salk Institute have created a stem-cell model for the premature ageing illness that should facilitate aging related studies.

Epigenetics in Stem Cells

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