2014 marks ;xSTx;i;xETx;Cell’s;xSTx;/i;xETx; 40th anniversary, and over the year we have looked back at how discoveries of the last four decades have molded our understanding of biology.;xNLx;;xNLx;Please join us and scroll along as we revisit a selection of the exceptional scientific work—both landmark papers and essential reviews—published in the last 40 years. Each paper’s entry features a link to the original work or, for select entries, links to an “Annotated Classic,” which includes the original paper and accompanying reflections of a leading scientist, considering the work from our current vantage point. Our last installment includes a harbinger of the interplay between microbiota and mammalian hosts in 2004, revolutionary papers in 2006 and 2007 unlocking cellular reprogramming, the discovery of beige adipocytes in 2012, and the first example of CRISPR-based genome editing in a nonhuman primate in 2014. In addition to landmark publications, there were innovative developments at the journal in this decade with the complete redesign of the print journal and the creation of Leading Edge in late 2005 and the restructuring of the online display of the article in 2010. Keeping pace with the changing nature of biological research, over the decade ;xSTx;i;xETx;Cell;xSTx;/i;xETx; added new article types, introduced guidelines for the organization of supplementary material, and expanded the journal's web-based content to bring editors’ and authors' excitement and perspective on individual papers to the readership.
"To my knowledge, the term nucleosome is introduced here for the first time." - Job Dekker
"This is the first description of an intron! The authors must have jumped for joy when they figured out what they discovered." - Brenton R. Graveley
Volume 13, Number 1, January 1978
"...flexibility of the genome within an individual, not just between individuals, was discovered to be part of evolution's toolbox." - David G. Schatz
"…somehow I thought it might be too good to be true." - Paul Nurse
"The discussion of what is the crucial replicative form of PrP aggregates is still ongoing." - Adriano Aguzzi
"The ingenious microtubule gliding assay used here opened the door to the definitive discovery of other motors…." -Trina A. Schroer
"These results show that the repeats are very likely TTGGGG, repeated over and over!" - Steven Artandi
"This paper showed that cell death was a normal part of development in a multicellular animal." - David L. Vaux
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