PATHOPAD: Through space and time we follow the path of pathology.

Pathopad tells the history of anatomy and pathology. A never ending story of scientific paradigms over the centuries. Contact us at pathopad@gmail.com

We present a short movie about the scope of Pathopad on the 2013 time line story: "This is PATOPATH.... an introduction.";xNLx;;xNLx;Pathopad is started by Jan Hein van Dierendonck, Frans Prins and Ronald van Eijk. ;xNLx;Jan Hein is a scientist, illustrator and journalist. Texts and scripts are mainly from his hand. ;xNLx;Frans is the technical specialist and directs movies and collects images for the project. ;xNLx;Ronald is a laboratory researcher in Pathology and is the timeline administrator.

0460 BC-01-01 11:04:17

Hippocrates

Hippocrates (Kos, ca 460 BC – Larissa, ca AD 365). "The father of western medicin and the founder of the Hippocratic School of Medicine

1017-08-01 00:00:00

Constantine the African

Constantine the African (c. 1020- d. before 1099) Born in Carthage (modern Tunisia) in North Africa. Why on pathopad: Compiled a libray of writings, mostly translations of ancient Arabic masters in medicine.

1080-08-01 00:00:00

Liber pantegni

Ca 1890: Liber pantegni (παντεχνῆ: all medical arts/techniques) The oldest known manual of Western medicine is in a safe of the Royal Library in The Hague.

1493-08-01 00:00:00

Paracelsus

Born Philippus Aureolus Theophrastus Bombastus von Hohenheim, (Egg, 11 November or 17 December 1493 – Salzburg, 24 September 1541) was a Swiss German. He was equally a controversial pioneer of homeopathy as of modern toxicology and critisised scholastic methods in medicine, science and theology.

1514-08-01 00:00:00

Andreas Vesalius

Andreas Vesalius; born Andries van Wezel ( Brussels, 31 December 1514 – Zakynthos, 15 October 1564) was a Brabantian (in modern-day Belgium). Vesalius was author of one of the most influential books on human anatomy, De humani corporis fabrica (On the Fabric of the Human Body).

1543-08-01 00:00:00

The humani corporis... (A. Vesalius). With Video

The humani corporis fabrica libri septem is a collection of textbooks on human anatomy written by Andreas Vesalius (1514–1564) and published in 1543. The Fabrica emphasized the priority of dissection and what has come to be called the "anatomical" view of the body, seeing human internal functioning as an essentially corporeal structure filled with organs arranged in three-dimensional space.

1575-01-01 00:00:00

Leiden University

Leiden University was founded in 1575 at the Rapenburg in Leiden

1593-08-01 00:00:00

Nicolaes Tulp

Nicolaes Tulp; born Claes Pieterszoon (Amsterdam, 9 October 1593 – The Hague, 12 September 1674), was a Dutch and is well known as the subject of Rembrandt's famous painting "The Anatomy Lesson of Dr Nicolaes Tulp" and became Mayor in Amsterdam.

1593-08-01 00:00:00

Leiden Anatomical Theatre

One of the first anatomical theatres in Europe was established in leiden. A reconstruction of this theatre can still be visitied in the Boerhaave museum in Leiden

1594-08-01 00:00:00

Anatomical Theatre Padua. With Video

The first anatomical theatre was built at the University of Padua in 1594 and is still preserved

1614-03-15 00:00:00

Franciscus Sylvius

Franciscus Sylvius; born François de le Boë, (Hanau, 15 March 1614 – Leiden, 19 November 1672), lived from the age of 25 in Holland. In 1832 his name was attached to the then discovered mineral Sylvite He was an important reformer, both of of medical theory and medical (bed-side) teaching.

1617-01-01 00:00:00

Anatomy lesson of Dr. Willem van der Meer. With Video

Anatomy lesson of Dr. Willem van der Meer by Michiel Janszoon van Miervelt (1576-1641) and Pieter Michielszoon van Mierenvelt (1596-1623)

1632-08-01 00:00:00

The Anatomy Lesson of Dr. Nicolaes Tulp. With Video

Oil painting by Rembrandt housed in the Mauritshuis museum in The Hague

1632-10-24 00:00:00

Antonie Philips van Leeuwenhoek. With Video

Antonie van Leeuwenhoek (October 24, 1632, Delft – August 26, 1723, Delft) was a Dutch tradesman and scientist and is commonly known as "the Father of Microbiology". He is best known for his work on the improvement of the microscope.

1635-08-01 00:00:00

Caecilia Hospital

The original nunnery of St Caecilia dates from the early 15th century. Originally a nunnery, the building had become municipal property after the Reformation and shortly before 1600 was converted into a ‘plague hospital and madhouse’. In 1635 it became an University hospital. It was here, around 1720, that Herman Boerhaave gave his famous sickbed lessons that drew medical students to Leiden from around the world.

1638-08-01 00:00:00

Frederik Ruysch

Frederik Ruysch (’s-Gravenhage, Marche 23, 1638, Amsterdam Februari 22, 1731) made several developments in the preservation of anatomical specimen and created craftfull expositions of bodyparts.

1656-01-01 00:00:00

The anatomy lesson of Dr. Jan Deyman. With Video

Originally a group portrait painted by Rembrandt. In 1723 the original work was almost completely destroyed by fire. In this remaining part Dr. Deyman performs a brain autopsy while his assistand is having the top of the skull in his hand.

1664-08-01 00:00:00

Sylvius Home and Laboratory

In 1669 Sylvius founded the first academic chemical laboratory. For this reason, the building in which much of the Leiden University chemistry and natural science faculties are housed has the name Sylvius Laboratory.

1665-02-25 00:00:00

Micrographia by Robert Hooke

'Robert Hooke was a British scientist who was the first to use the word “cell”, published, in 1665, his work about microscopic observations : Micrographia. It became a best-seller.

1668-08-01 00:00:00

Herman Boerhaave

Herman Boerhaave, 31 December 1668 Voorhout – 23 September 1738 Leiden) was a Dutch botanist, humanist and physician of World fame. He is regarded as the founder of clinical teaching and of the modern academic hospital.

1670-08-01 00:00:00

Anatomy Lesson of an adult by F. Ruysch. With Video

Adriaan Baecker (1635/36-1684). Anatomy Lesson of an adult by prof. Frederik Ruysch. 1670: commissioned by Surgeon’s Guild, Amsterdam

1671-08-01 00:00:00

Praxeos medicae idea (F. Sylvius)

The most important work Sylvius published was Praxeos medicae idea nova (New Idea in Medical Practice, 1671).

1676-08-01 00:00:00

Microscope (A. van Leeuwenhoek)

Leeuwenhoek made more than 500 optical lenses. He also created at least 25 microscopes, of differing types, of which only nine survived. His microscopes were made of silver or copper frames, holding hand-made lenses. Those that have survived are capable of magnification up to 275 times. It is suspected that Leeuwenhoek possessed some microscopes that could magnify up to 500 times. Although he has been widely regarded as a dilettante or amateur, his scientific research was of remarkably high quality

1682-02-25 00:00:00

Giovanni Battista Morgagni

Giovanni Battista Morgagni (25 February 1682 Forli, Italy – 6 December 1771 Padua, Italy) was an Italian anatomist, celebrated as the father of modern anatomical pathology.

1683-08-01 00:00:00

Anatomy Lesson of an Infant by F. Ruysch. With Video

Jan van Neck (1635-1714) Anatomical lesson of an infant by Prof. Frederik Ruysch; 1670: commissioned by Surgeon’s Guild, Amsterdam Theatrum Anatomicum, Kleine Vleeshal, Nes, Amsterdam.

1689-01-12 00:00:00

Van Leeuwenhoeks Eelviewer with video

In order to demonstrate blood circulation Van Leeuwenhoek adapted his microscope and he explaine to the Royal Society how his "aalkijker" eelglass could be used to enjoy "the satisfying sight of the circulatiing blood"

1697-02-05 00:00:00

William Smellie

William Smellie (5 February 1697, Lanark – 5 March 1763, Lanark) was a Scottish obstetrician. His work made major progress in the medical discipline of obstetrics.

1699-11-01 00:00:00

Two surgeons with a wax injected heart. With Video

Painted by Jurriaan Pool (1666-1745)

1710-12-01 00:00:00

Jacob Hovius (Video in Dutch)

In 1736 Jacob Hovius, Physician in the Amsterdam "Buitengasthuis" starts to collect bones with all kind of anomalies. In 1772 he donated his collection to the Amsterdam surgeons' guild for educational purposes. His only condition is that there is a special case made for it. This cabinet, the "Hovius kast", originally located in the Waag in Amsterdam can now be seen in the Frolik Museau in the AMC in Amsterdam.

1718-05-23 00:00:00

William Hunter

William Hunter (23 May 1718, Long Calderwood – 30 March 1783, London) was a Scottish anatomist and physician. He was a leading teacher of anatomy, and the outstanding obstetrician of his day.

1728-02-13 11:49:07

John Hunter

John Hunter FRS (13 February 1728 East Kilbride, Scotland – 16 October 1793, London). This distinguished Scottish surgeon was promoted careful observation as a scientific approach in medicine.

1754-02-05 00:00:00

A Sett of Anatomical.. (W. Smellie)

1754, London William Smellie. A Set of Anatomical Tables, with Explanations, and an Abridgement, of the Practice of Midwifery.

1761-08-01 00:00:00

De Sedibus et causis...With Video

De sedibus, et causis morborum per anatomen indagatis libri quinque. Bologna, 1761. Publisher: Venetiis, Ex Typographia Remondiniana Language: Latin

1761-10-27 00:00:00

Matthew Baillie

Matthew Baillie (27 October 1761, Shotts Manse, Lanarkshire, Scotland – 23 September 1823, Duntisbourne, Gloucestershire, England) was a Scottish physician and pathologist. His 1793 book is considered the first systematic study of pathology.

1771-01-01 00:00:00

Influential works of J. Hunter

1771 The Natural History of the Human Teeth. 1778 A Practical Treatise on the Diseases of the Teeth.

1774-08-01 00:00:00

The Anatomy of the...(W. Hunter)

The Anatomy of the Human Gravid Uterus, Exhibited in Figures

1793-08-01 00:00:00

The morbid anatomy.. (M. Baillie)

The morbid anatomy of some of the most important parts of the human body. This is considered to be the first systematic atlas of pathology and the first treatise on pathology in English. The 73 plates were from specimen in the John Hunter Museum and engraved by William Clift.

1813-09-01 00:00:00

Hunterian Museum. With Video

John Hunter's collection was purchased by the government in 1799 and given to the Company (later The Royal College) of Surgeons. The collection formed the basis for a museum constructed as part of the new Royal College of Surgeons of London's building on the south side of Lincoln's Inn Fields.

1821-10-31 00:00:00

Rudolph Carl Virchow

Rudolph Carl Virchow, (13 October 1821 Schivelbein, Prussia– 5 September 1902, Berlin) currently known as "the father of modern pathology", was a German doctor, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician, known for his advancement of public health.

1843-07-07 00:00:00

Camillo Golgi

Camillo Golgi, born in Italy, was a physician, pathologist, scientist, and Nobel laureate. Several structures and phenomena in anatomy and physiology are named for him, including the Golgi apparatus, the Golgi tendon organ, and the Golgi tendon reflex.

1858-08-01 00:00:00

Cellularpathologie (R. Virchow)

In 1847 the Berliner pathologist Rudolph Virchow and his friend and colleague Benno Reinhardt had begun producing the Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, which Virchow edited alone from 1852 until his death in 1902 and which is still world-famous as Virchow’s Archives.

1858-08-01 00:00:00

David Paul von Hansemann

Was a coworker of Virchow and introduced the term "anaplasia" and proposed that normal cells are converted into tumor cells when they acquire chromosomal abnormalities.

1862-08-01 00:00:00

Theodor Heinrich Boveri

Theodor Heinrich Boveri was a German biologist. Theodore Boveri applied his observations of deviding sea urchin eggs and their abnormalities to what he perceived to be the genetic basis of malignancy

1877-01-01 00:00:00

Hematoxylin and Eosin (H&E) staining (Video in Dutch)

In 1877 N. Wissozky was the first to describe the combination of the hematoxylin and eosin (H&E) dyes. His finding was described in Archiv für mikroskopische Anatomie (1877) December 1877, Volume 13, Issue 1, pp 479-496. H&E staining is still in use in pathology labs all around the world.

1893-08-01 00:00:00

Tissue Fixation (F. Blum)

In 1893 the fixative properties of formaldehyde were accidentally found by the German physician named Ferdinand Blum (1865–1959) in 1893. Blum was involved in a research project on the antiseptic properties of formaldehyde. While working with a 4% aqueous solution of formaldehyde, Blum discovered that his wet fingers became stiff. He wrote a paper describing his finding, and this was the beginning of the widespread use of formaldehyde as a cell preservative.

1895-07-07 00:00:00

Aldred Scott Warthin and the Lynch Syndrome

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720817/ Aldred Scott Warthin, MD, PhD, Chairman of the Department of Pathology at the University of Michigan in Ann Arbor, reported the first family with the disease we now call Lynch Syndrome

1914-08-01 00:00:00

Zur Frage der Enstehung...(T. Boveri)

In his book Zur frage der Enstehung Maligner Tumoren Boveri formulated 20 hypotheses on cancer biology which have almost become verified in the 100 years after the writing of his book.

1916-07-08 00:00:00

The vascular origin of hematopoietic cells

In the early 1900th embryologists reported sites of hematopoietic activity in the vascular wall of mid-gestation vertebrate embryos, and postulated the transient existence of a blood generating endothelium during ontogeny.

1927-07-01 00:00:00

J.S.Ploem. With Video

Johan Sebastiaan Ploem (born 25 August 1927, Sawahlunto, Sumatra Indonesia) is a Dutch microscopist and digital artist, who made significant contribution to the field of fluorescence microscopy

1939-12-01 00:00:00

De anatomische les 1939 (J.J. Schoonhoven)

Johannes Jacobus "John" Schoonhoven ( Delft , June 26th 1914 - there, July 31 1994 ) was a Dutch visual artist. studied from 1930 to 1934 at the Royal Academy of Art in The Hague . He worked from 1946 to 1979 at the Central Department of Buildings (then state) PTT . The artistry of Schoonhoven took place in the evenings and weekends free.

PATHOPAD: Through space and time we follow the path of pathology.

Launch
Copy this timeline Login to copy this timeline 3d Game mode

Contact us

We'd love to hear from you. Please send questions or feedback to the below email addresses.

Before contacting us, you may wish to visit our FAQs page which has lots of useful info on Tiki-Toki.

We can be contacted by email at: hello@tiki-toki.com.

You can also follow us on twitter at twitter.com/tiki_toki.

If you are having any problems with Tiki-Toki, please contact us as at: help@tiki-toki.com

Close

Edit this timeline

Enter your name and the secret word given to you by the timeline's owner.

3-40 true Name must be at least three characters
3-40 true You need a secret word to edit this timeline

Checking details

Please check details and try again

Go
Close