Innovations in Biological Imaging through History

Follow this timeline to see some of the major milestones in the development of microscopy techniques for biological imaging.

This timeline was developed for QSTORM by Anna (Tsinberg) Scherer in May 2012, and will be updated and enhanced from time to time...

PET Scan shows body processes

Positron emission tomography (PET) produces 3D images of biological processes inside the body.

MRI images the body safely

Magnetic resonance imaging (MRI) produces 2D and 3D images of the structures inside the body in a harmless manner.

First Microscope

The first microscope was created by placing two lenses in a tube.

What's in a name?

The word "microscope" is coined.

Life Under The Microscope

First microscope observations are published, including images of the flea and cork "cells".

Bacteria and Sperm Cells

Bacteria and sperm cells are observed using a single lens microscope.

No More Blurry Images

Blurring of microscope images due to chromatic aberration was reduced.

Light Microscopy Has Its Limits

For most of the twentieth century, it was widely believed that light microscopy could not resolve objects smaller than 150 - 200 nanometers.

Stains and Fluorescent Dyes

Stains and fluorescent dyes revealed different components of cells.

Fluorescence Microscope

"If and to what degree fluorescence microscopy will widen the possibilities of microscopic imaging only the future will show." -Oskar Heimstadt

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